Volume 8: Variant CJD
Table of Contents

1 Introduction

2 History of CJD surveillance up to 1990
   Surveillance in the UK before the emergence of BSE
   BSE discovery and the recommendations for CJD surveillance

3 Establishment of the CJD Surveillance Unit
   Establishment
   Terms of reference
   Funding and resources
   Review of the CJDSU by the Allen Committee
   Public Health Laboratory Service involvement

4 Work of the CJD Surveillance Unit
   Retrospective study of CJD
   Prospective study of CJD
   Development of the questionnaire
   Development of the statistical analysis - epidemiology
   Results of the surveillance (1991-95)
   Fifth Annual Report (1996)

5 Emergence of variant CJD
   Chronological account of the emergence of vCJD
   Evolution of knowledge leading to the identification of new variant CJD and the hypothesis of causal link with BSE between late 1995 and early March 1996
   Relevant events after 20 March 1996
   Discussion on the work of the CJD Surveillance Unit (CJDSU)

Annex to Chapter 5: Information on patients under 50 referred to the CJDSU before 20 March 1996

6 Diagnosis, treatment and care of vCJD patients
   Symptoms of vCJD
   Diagnosis of vCJD by the medical profession
   Tests performed
   Treatment and care of vCJD patients
   Discussion of diagnosis, treatment and care of vCJD victims

Annex 1: CJDSU questionnaires

Annex 2: Summary tables on the clinical investigative and pathological data on suspect or confirmed cases of CJD aged less than 50 years

List of acronyms

Who's who

Index

   Table 4.1: Development of the CJD questionnaire
   Table 4.2: Deaths from Creutzfeldt-Jakob Disease
   Table 5.1: Number of definite and probable cases of vCJD since 1995
   Figure 5.1: Geographical distribution of places of residence of vCJD cases at onset of symptoms
   Figure 5.2: Cases of vCJD by date of onset, notification, death and confirmation